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  • POT-4 peptide

POT-4 peptide

Not For Human Use, Lab Use Only.

Cat.#: 319798

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* Buy 1 get 1 free (?) What is TFA?

Special Price 649.00 USD

Availability: 1-2 weeks
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Product Information

  • Product Name
    POT-4 peptide
  • Documents

    Batch to batch variation of the purity

  • Sequence
    Ac-ICV{Trp(Me)}QDWGAHRCT-NH2 (Disulfide bridge:Cys2-Cys12)
  • Length (aa)
    13
  • Peptide Purity (HPLC)
    95%
  • Molecular Formula
    C72H102N22O18S2
  • Molecular Weight
    1627.85
  • CAS No.
    934461-40-2
  • PubChem CID
    16158103
  • Source
    Synthetic
  • Form
    Powder
  • Description

    POT-4 is a cyclic peptide derived from compstatin, a potent inhibitor of complement component C3. It exhibits high binding affinity to C3, effectively preventing its cleavage into active fragments C3a and C3b. This inhibition disrupts the complement cascade, thereby reducing local inflammation and downstream effects. In experimental models, POT-4 has demonstrated significant complement inhibition with minimal toxicity, making it a promising candidate for further study.

  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • Troutbeck R, Al-Qureshi S, Guymer RH. Therapeutic targeting of the complement system in age-related macular degeneration: a review. Clin Exp Ophthalmol. 2012 Jan-Feb;40(1):18-26. doi: 10.1111/j.1442-9071.2011.02581.x. PMID: 22304025.
  • About TFA salt

    Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

    Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

    Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

    In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

  • Molar Concentration Calculator

  • Dilution Calculator

  • Percent Concentration Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"