Ponericin-Q42 (insects, arthropods, invertebrates, animals, UCLL1a) peptide

Ponericin-Q42 (insects, arthropods, invertebrates, animals, UCLL1a) peptide

• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

H-FWGAVWKILSKVLPHIPGTVKWLQEKV-OH

H-Phe-Trp-Gly-Ala-Val-Trp-Lys-Ile-Leu-Ser-Lys-Val-Leu-Pro-His-Ile-Pro-Gly-Thr-Val-Lys-Trp-Leu-Gln-Glu-Lys-Val-OH

27

95.69%

C₁₅₆H₂₃₉N₃₇O₃₃

3160.78

Synthetic

Powder

Ponericin-Q42 is a linear antimicrobial peptide isolated from the venom of the ant species Ectatomma quadridens. It is one of three peptides with low similarity to the well-known ponericin peptides found in the ant venom.
The peptide has a partially helical secondary structure, even in aqueous environments, which is unusual for short linear peptides.
Ponericin-Q42 has been shown to possess marked antibacterial activity against both Gram-positive and Gram-negative bacteria at low micromolar concentrations. For example, it is active against A. globiformis VKM Ac-1112, B. subtilis VKM B-501, E. coli MH1 (MIC 0.2-0.6 uM), E. coli DH5a, and P. aeruginosa PAO1 (MIC 5-10 uM). It also exhibits broad-spectrum cytolytic activity against different bacterial strains, human erythrocytes, and chronic myelogenous leukemia K562 cells. Ponericin-Q42 also has weak toxic activity on flesh fly larvae, with an LD50 of approximately 105 mg/g.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• Pluzhnikov KA, Kozlov SA, Vassilevski AA, Vorontsova OV, Feofanov AV, Grishin EV. Linear antimicrobial peptides from Ectatomma quadridens ant venom. Biochimie. 2014;107 Pt B:211-5.
• Kozic M, Fox SJ, Thomas JM, Verma CS, Rigden DJ. Large scale ab initio modeling of structurally uncharacterized antimicrobial peptides reveals known and novel folds. Proteins. 2018 May;86(5):548-565.

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.