Polybia-MPI peptide

Polybia-MPI peptide

• COA/MS/HPLC Report
• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

IDWKKLLDAAKQIL-NH2

H-Ile-Asp-Trp-Lys-Lys-Leu-Leu-Asp-Ala-Ala-Lys-Gln-Ile-Leu-NH2

14

97.2%

C₇₈H₁₃₂N₂₀O₁₉

1654

872043-01-1

Synthetic

Powder

Have anti-biofilm and antifungal activities against C. albicans and C. glabrata (Wang K et al. 2014). A mast cell lytic peptide, chemotaxis for polymorphonucleated leukocytes (PMNL). Not toxic to rat erythrocytes. Helix in SDS or TFE. Replacement of residue 7, 8, or 9 by a proline led to reduced helicity as well as antitumor activity (Wang et al. 2008) Peptides 29: 963-968. Animal model:mouse: A single atom change (CO-NH2 to CS-NH2) of MPI improved peptide stability to serum proteases and better inhibited sarcoma xenograft tumor (S180) growth from 18 (WT) to 38% (mutant) using a Kunming mouse model (Zhang W et al. 2010 Peptides 31:1832-8). Updated 9/6/12; 3/2014 GW. Polybia-MPI has Antibacterial activity. Polybia-MPI was found in venom, social wasp, Polybia paulista.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• Souza BM, Mendes MA, Santos LD, et al. Structural and functional characterization of two novel peptide toxins isolated from the venom of the social wasp Polybia paulista. Peptides. 2005;26(11):2157-64.

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.