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Recombinant PNMT protein (His tag)

Recombinant PNMT protein (His tag)

Cat.#: 544380

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Product Information

  • Product Name
    Recombinant PNMT protein (His tag)
  • Documents
  • Description

    Recombinant Phenylethanolamine N-methyltransferase (PNMTase) (EC 2.1.1.28), a human enzyme fragment (residues 2-282) engineered for high stability and solubility, ideal for structural studies and biochemical assays investigating catecholamine metabolism.

    Phenylethanolamine N-methyltransferase (PNMTase) is a key enzyme in the biosynthesis of epinephrine (adrenaline), catalyzing the S-adenosyl-L-methionine-dependent transmethylation of norepinephrine (noradrenaline). It also methylates substrates such as phenylethanolamine, octopamine, and normetanephrine, playing a critical role in stress response and neurotransmitter regulation. This recombinant fragment encompasses the functional domain, enabling focused research on its catalytic mechanisms and physiological relevance.

  • Protein name
    Phenylethanolamine N-methyltransferase
  • Uniprot ID
    P11086
  • Gene Name
    PNMT; PENT
  • Source/Expression Host
    E. coli
  • Expression Plasmid/cDNA
    DNA encoding 2-282 aa (P11086) were fused with 6His tag.
  • Protein Species
    Human
  • Molecular weight
    Predictes a molecular mass of 32.38 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 32 kDa band.
  • Purity
    >85%, by SDS-PAGE with Coomassie Brilliant Blue staining.
  • Activity
    Not tested.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"