PLP (139-151) peptide

PLP (139-151) peptide

• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

H-HCLGKWLGHPDKF-OH

H-His-Cys-Leu-Gly-Lys-Trp-Leu-Gly-His-Pro-Asp-Lys-Phe-OH

13

95.8%

C₇₂H₁₀₄N₂₀O₁₆S

1537.78

Synthetic

Powder

PLP (139-151), or proteolipid protein (139-151) is a myelin proteolipid protein (PLP) fragment. PLP is one of the major protein constituents of myelin, along with myelin oligodendrocyte glycoprotein (MOG) and myelin basic protein (MBP), which between them make up 15% - 25% of dry weight, the rest being mainly lipids. Myelin has an essential insulating role for nerves, allowing normal motor function, sensory function and cognition. Animals immunized with PLP (139-151) develop severe experimental allergic encephalomyelitis (EAE) and this model is widely used to study human multiple sclerosis (MS).

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• Tuohy et al (1989) Identification of an encephalitogenic determinant of myelin proteolipid protein for SJL mice. J.Immunol. 142 1523 PMID: 2465343
• Kuchroo et al (1991) Induction of experimental allergic encephalomyelitis by myelin proteolipid-protein-specific T cell clones and synthetic peptides. Pathobiology 59 305 PMID: 1716908
• Tigno-Aranjuez et al (2009) Encephalitogenicity of Complete Freund's Adjuvant Relative to CpG Is Linked to Induction of Th17 Cells. J. Immunol. 183(9) 5654 PMID: 19812193

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.