Pleurain-R1 peptide

Pleurain-R1 peptide

• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

H-CVHWMTNTARTACIAP-OH

H-Cys-Val-His-Trp-Met-Thr-Asn-Thr-Ala-Arg-Thr-Ala-Cys-Ile-Ala-Pro-OH

16

95.94%

C₇₅H₁₁₉N₂₃O₂₁S₃

1775.08

Synthetic

Powder

Pleurain-R1 is an antioxidant and antimicrobial peptide identified from the skin secretions of Rana pleuraden (China, Asia), showing potent antioxidant and antibacterial activity.
Pleurain-R1 contains amino acid residues such as methionine, free cysteine, tyrosine, and proline, contributing to its antioxidant function.
The thiol group in Cys 10 of Pleurain-R1 is responsible for binding ABTS and reducing ABTS radical, indicating its antioxidant mechanism.
Pleurain-R1 is part of a diverse group of antioxidant peptides found in amphibian skin, highlighting the importance of proline residues in their antioxidant capabilities.
Pleurain-R1 also has Antibacterial, Antifungal activity. Active against E. coli (MIC 100 uM), S. aureus (MIC 25 uM), B. subtilis (MIC 100 uM), and C. albicans (MIC 50 uM).

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• Yang H, Wang X, Liu X, et al. Antioxidant peptidomics reveals novel skin antioxidant system. Mol Cell Proteomics. 2009;8(3):571-83.
• Yan H, Liu Y, Tang J, Mo G, Song Y, Yan X, Wei L, Lai R. A novel antimicrobial peptide from skin secretions of the tree frog Theloderma kwangsiensis. Zoolog Sci. 2013 Sep;30(9):704-9.

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.