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  • Plecanatide peptide

Plecanatide peptide

Not For Human Use, Lab Use Only.

Cat.#: 319823

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* Buy 1 get 1 free (?) What is TFA?

Special Price 529.00 USD

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Product Information

  • Product Name
    Plecanatide peptide
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    H-NDECELCVNVACTGCL-OH
  • Sequence
    H-Asn-Asp-Glu-Cys-Glu-Leu-Cys-Val-Asn-Val-Ala-Cys-Thr-Gly-Cys-Leu-OH
  • Length (aa)
    16
  • Peptide Purity (HPLC)
    95.52%
  • Molecular Formula
    C65H104N18O26S4
  • Molecular Weight
    1681.88
  • CAS No.
    467426-54-6
  • Source
    Synthetic
  • Form
    Powder
  • Description

    Plecanatide is a synthetic analog of the endogenous peptide uroguanylin, differing by a single amino acid substitution where aspartic acid at position 3 is replaced with glutamic acid. It functions as a guanylate cyclase-C (GC-C) receptor agonist, stimulating the production of cyclic guanosine monophosphate (cGMP) in a pH-dependent manner. Structurally, plecanatide maintains the disulfide bond-forming cysteine residues characteristic of uroguanylin, which are critical for its biological activity.

    The peptide exhibits potent cGMP-stimulatory activity in human colon carcinoma T84 cells, with an EC50 of 1.9 × 10-7 mol/L. Its mechanism involves activation of GC-C receptors localized on the apical surface of intestinal epithelial cells, influencing ion transport, mucosal homeostasis, and barrier function. Plecanatide demonstrates resistance to proteolytic degradation, enabling its functional stability in the gastrointestinal lumen.

  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • Shailubhai K, Palejwala V, Arjunan KP, Saykhedkar S, Nefsky B, Foss JA, Comiskey S, Jacob GS, Plevy SE. Plecanatide and dolcanatide, novel guanylate cyclase-C agonists, ameliorate gastrointestinal inflammation in experimental models of murine colitis. World J Gastrointest Pharmacol Ther. 2015 Nov 6;6(4):213-22. doi: 10.4292/wjgpt.v6.i4.213. PMID: 26558155; PMCID: PMC4635161.
  • About TFA salt

    Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

    Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

    Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

    In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

  • Molar Concentration Calculator

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  • Percent Concentration Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"