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Product Name
Recombinant PICK1 protein (His tag)
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Description
Recombinant Human PICK1 (PRKCA-binding protein) fragment (aa 1-356), encompassing the full PDZ domain, is a high-quality tool for investigating protein-protein interactions, receptor clustering, and synaptic plasticity mechanisms in neuroscience and cell biology research.
PICK1 (Protein interacting with C kinase 1) is an adapter protein that organizes subcellular localization of membrane proteins through PDZ domain interactions. It plays critical roles in synaptic plasticity by regulating AMPA receptor trafficking and internalization, modulates actin polymerization by inhibiting Arp2/3 complex activity, and is involved in receptor clustering mechanisms. The protein localizes to cytoplasmic perinuclear regions, membranes (as both peripheral and lipid-anchored protein), postsynaptic densities, synaptosomes, and the cytoskeleton, particularly at excitatory synapses, highlighting its importance in neuronal signaling and structural organization.
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Protein name
PRKCA-binding protein
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Uniprot ID
Q9NRD5
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Gene Name
PICK1; PRKCABP
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 1-356 aa (Q9NRD5) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 41.93 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 44 kDa band.
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Purity
>86%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"