Cart 2
Recombinant PI4KA protein (His tag)

Recombinant PI4KA protein (His tag)

Cat.#: 542319

Size:

Special Price 294.7 USD

Availability: 3-4 weeks
- +

Add to cart to get an online quotation

Product Information

  • Product Name
    Recombinant PI4KA protein (His tag)
  • Documents
  • Description

    Recombinant Phosphatidylinositol 4-kinase alpha (PI4K-alpha) fragment (residues 299-525) from Homo sapiens, engineered for stability and solubility to facilitate structural and biochemical studies of this key enzyme in phosphoinositide signaling pathways.

    Phosphatidylinositol 4-kinase alpha (PI4K-alpha) catalyzes the phosphorylation of phosphatidylinositol (PtdIns) in the first committed step of inositol-1,4,5-trisphosphate production, a crucial second messenger in cellular signaling. The enzyme localizes to both the cytoplasm and cell membrane, with plasma membrane localization mediated by the PI4K complex through association with EFR3, TTC7, and HYCC proteins, and regulated by TMEM150A. This fragment represents a stable, soluble unit of PI4K-alpha, enabling detailed investigation of its structural and functional properties.

  • Protein name
    Phosphatidylinositol 4-kinase alpha
  • Uniprot ID
    P42356
  • Gene Name
    PI4KA; PIK4; PIK4CA
  • Source/Expression Host
    E. coli
  • Expression Plasmid/cDNA
    DNA encoding 299-525 aa (P42356) were fused with 6His tag.
  • Protein Species
    Human
  • Molecular weight
    Predictes a molecular mass of 27.50 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 27 kDa band.
  • Purity
    >89%, by SDS-PAGE with Coomassie Brilliant Blue staining.
  • Activity
    Not tested.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"