[Des-Arg9]-Bradykinin peptide

[Des-Arg9]-Bradykinin peptide

• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

RPPGFSPF

Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe

8

97.9%

C₄₄H₆₁N₁₁O₁₀

904

15958-92-6

Synthetic

Powder

[Des-Arg⁹]-Bradykinin is a bioactive peptide derived from the enzymatic processing of bradykinin, specifically through the removal of the C-terminal arginine residue by carboxypeptidases. This modification confers selectivity for the bradykinin B1 receptor subtype, which is typically upregulated under inflammatory conditions. Unlike the constitutively expressed B2 receptor, the B1 receptor is induced by proinflammatory cytokines and mediates prolonged inflammatory and nociceptive responses. [Des-Arg⁹]-Bradykinin plays a significant role in various pathophysiological processes, including inflammation, pain, and vascular permeability.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• Roseghini M, Falconieri erspamer G, Severini C, Simmaco M. Biogenic amines and active peptides in extracts of the skin of thirty-two European amphibian species. Comp Biochem Physiol C, Comp Pharmacol Toxicol. 1989;94(2):455-60.
• Leeb-Lundberg LM, Marceau F, Müller-Esterl W, Pettibone DJ, Zuraw BL. International union of pharmacology. XLV. Classification of the kinin receptor family: from molecular mechanisms to pathophysiological consequences. Pharmacol Rev. 2005 Mar;57(1):27-77. doi: 10.1124/pr.57.1.2. PMID: 15734727.

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.