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Product Name
Recombinant PHKG2 protein (His tag)
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Description
Recombinant Human Phosphorylase b kinase gamma catalytic chain, liver/testis isoform (PHK-gamma-LT) fragment (amino acids 1-358) is a high-purity protein encompassing the complete protein kinase domain. This fragment serves as an essential tool for studying glycogenolysis regulation, specifically investigating the catalytic mechanisms of PHK-gamma-T in phosphorylating and activating glycogen phosphorylase.
The full-length PHK-gamma-LT (encoded by gene PHKG2) functions as the catalytic subunit of phosphorylase b kinase, playing a critical role in neural and hormonal regulation of glycogen breakdown. It mediates glycogenolysis by phosphorylating and activating glycogen phosphorylase (PYGM), with emerging evidence suggesting specific regulatory functions in testicular glycogen metabolism. This protein represents a key enzymatic component in energy metabolism pathways, with demonstrated phosphorylation activity against PYGM in experimental settings.
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Protein name
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform
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Uniprot ID
P15735
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Gene Name
PHKG2
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 1-358 aa (P15735) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 42.91 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 45 kDa band.
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Purity
>88%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"