Periplanetasin-4 peptide

Periplanetasin-4 peptide

• COA/MS/HPLC Report
• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

H-LRHKVYGYCVLGP-NH2

H-Leu-Arg-His-Lys-Val-Tyr-Gly-Tyr-Cys-Val-Leu-Gly-Pro-NH2

13

95.67%

C₇₀H₁₁₀N₂₀O₁₅S

1503.82

Synthetic

Powder

Periplanetasin-4 is a novel antimicrobial peptide derived from the American Cockroach (Periplaneta americana). Periplanetasin-4 has diverse effects on fungal cells, including antimicrobial activity, induction of cell death with unique apoptotic and necrotic features, disruption of mitochondrial and vacuolar functions, and modulation of intracellular signaling pathways.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• Lee H, Hwang JS, Lee DG. Periplanetasin-4, a novel antimicrobial peptide from the cockroach, inhibits communications between mitochondria and vacuoles. Biochem J. 2019 Apr 26;476(8):1267-1284. doi: 10.1042/BCJ20180933. PMID: 30962256.

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.