Human CASK Kinase recombinant protein
Multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. Contributes to neural development and regulation of gene expression via interaction with the transcription factor TBR1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1.
Peripheral plasma membrane protein CASK
Protein short names
RP11-540L11.1; TNRC8; DXRIB1; PALS3; CMG; MRXSNA; DXPRI1; FLJ22219; CASK; CAGH39; FLJ31914; MGC7449; MLIN-2; FGS4; CAMGUK; LIN-2; MICPCH; RP23-278L4.1; LIN2
A DNA sequence encoding the human CASK (O14936-4) (Ala 2-Tyr 898) was expressed and purified with two additional amino acids (Gly & Pro) at the N-terminus.
The secreted recombinant human CASK consists of 899 amino acids and predicts a molecular mass of 102.1 KDa. The apparent molecular mass of the protein is approximately 102 KDa in SDS-PAGE under reducing conditions due to glycosylation.
> 90 % as determined by SDS-PAGE
Kinase activity untested
Human CASK Kinase Protein SDS-PAGE
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