Peptide HV2 (histidine-rich peptide)

Peptide HV2 (histidine-rich peptide)

• COA/MS/HPLC Report
• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

H-RRVHVHvPGVHVHVRR-NH2

H-Arg-Arg-Val-His-Val-His-Val-D-Pro-Gly-Val-His-Val-His-Val-Arg-Arg-NH2

16

98.41%

C₈₅H₁₄₃N₃₇O₁₆

1939.31

Synthetic

Powder

The peptide HV2 was identified as particularly effective, displaying strong antibacterial activity against Gram-negative bacteria, while being non-toxic to normal cells. HV2 operates by disrupting bacterial cell membranes, increasing permeability, and inhibiting bacterial movement and TNF-α production, indicating strong anti-inflammatory effects. These attributes suggest that HV2 is a promising candidate for antibiotic development.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• Dong N, Wang C, Zhang T, et al. Bioactivity and Bactericidal Mechanism of Histidine-Rich u03b2-Hairpin Peptide Against Gram-Negative Bacteria. Int J Mol Sci. 2019;20(16)

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.