Pep-1 peptide

Pep-1 peptide

• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

H-CGEMGWVRC-OH

H-Cys-Gly-Glu-Met-Gly-Trp-Val-Arg-Cys-OH

9

95.13%

C₄₂H₆₅N₁₃O₁₂S₃

1040.24

Synthetic

Powder

Pep-1, was discovered to tightly bind to the receptor and penetrate the BBB and BBTB. Recognizing the applicability of Pep-1 for targeted liposomal delivery, Jiao et al. functionalized liposomes loaded with Cilengitide to improve spatial distribution. Remarkably, cellular uptake was improved from 47.5% to 89.8% when Pep-1 was conjugated to the liposome surface, and in vivo studies exhibited a significant reduction in the tumor volume by targeted formulations in U87-bearing xenograft mice.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• Aronson MR, Medina SH, Mitchell MJ. Peptide functionalized liposomes for receptor targeted cancer therapy. APL Bioeng. 2021 Jan 25;5(1):011501. doi: 10.1063/5.0029860. PMID: 33532673; PMCID: PMC7837755.

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.