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  • Peceleganan peptide

Peceleganan peptide

Not For Human Use, Lab Use Only.

Cat.#: 319830

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* Buy 1 get 1 free (?) What is TFA?

Special Price 238.50 USD

Availability: 3 weeks
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Product Information

  • Product Name
    Peceleganan peptide
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    Ac-KWKSFLKTFKSAAKTVLHTALKAISS-NH2
  • Sequence
    Ac-Lys-Trp-Lys-Ser-Phe-Leu-Lys-Thr-Phe-Lys-Ser-Ala-Ala-Lys-Thr-Val-Leu-His-Thr-Ala-Leu-Lys-Ala-Ile-Ser-Ser-NH2
  • Length (aa)
    26
  • Peptide Purity (HPLC)
    95.25%
  • Molecular Formula
    C138H226N36O34
  • Molecular Weight
    2933.48
  • CAS No.
    850761-47-6
  • Source
    Synthetic
  • Form
    Powder
  • Description

    Peceleganan is an α-helical antimicrobial peptide (AMP) characterized by its low molecular weight, amphipathic structure, and net positive charge. It exhibits broad-spectrum antibacterial activity against both Gram-positive and Gram-negative bacteria, with minimal inhibitory concentrations (MICs) ranging from 1 to 8 μM. The peptide's mechanism of action involves disrupting bacterial cell membranes, leading to increased permeability and loss of barrier function.

    Peceleganan demonstrates functional synergy when combined with traditional antibiotics, enhancing their antibacterial efficacy. This synergy arises from the peptide's ability to compromise membrane integrity, facilitating antibiotic entry into bacterial cells. Its structural features, including hydrophobicity and charge distribution, contribute to its potent antimicrobial properties and selectivity for prokaryotic membranes.

  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • Feng Q, Huang Y, Chen M, Li G, Chen Y. Functional synergy of α-helical antimicrobial peptides and traditional antibiotics against Gram-negative and Gram-positive bacteria in vitro and in vivo. Eur J Clin Microbiol Infect Dis. 2015 Jan;34(1):197-204. doi: 10.1007/s10096-014-2219-3. Epub 2014 Aug 30. PMID: 25169965.
  • About TFA salt

    Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

    Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

    Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

    In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

  • Molar Concentration Calculator

  • Dilution Calculator

  • Percent Concentration Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"