PDSGR peptide

PDSGR peptide

• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

Ac-PDSGR-OH

Ac-Pro-Asp-Ser-Gly-Arg-OH

5

95.68%

C₂₂H₃₆N₈O₁₀

572.56

Synthetic

Powder

PDSGR peptide is a bioactive short peptide designed for nerve tissue engineering research. It features an acyl-blocked N-terminal, enhancing aggregation tendency, while its hydrophilic C-terminal with the PDSGR sequence remains open. However, its solubility in 20 mM HEPES buffer at pH 6 is poor due to the presence of a proline residue, which also leads to weak self-assembly ability, forming only a few small peptide segments. Despite these limitations, it is part of the exploration in developing effective scaffolds for nerve tissue engineering, with potential for further modifications or combinations to unlock its functionality in promoting cell behaviors and neural tissue regeneration.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• Sun W, Taylor CS, Gao Z, Gregory DA, Haycock JW, Zhao X. Co-assembling bioactive short peptide nanofibers coated silk scaffolds induce neurite outgrowth of PC12 cells. Int J Biol Macromol. 2024 Oct;278(Pt 2):134774. doi: 10.1016/j.ijbiomac.2024.134774. Epub 2024 Aug 16. PMID: 39154681.

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.