PDHPS1 peptide

PDHPS1 peptide

• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

H-IATTTASAATAAAIGATPRAK-OH

H-Ile-Ala-Thr-Thr-Thr-Ala-Ser-Ala-Ala-Thr-Ala-Ala-Ala-Ile-Gly-Ala-Thr-Pro-Arg-Ala-Lys-OH

21

95.1%

C₈₁H₁₄₃N₂₅O₂₈

1915.14

Synthetic

Powder

PDHPS1 (peptide deregulated in hypertrophic scar-1) is an endogenous peptide from skin tissue, whose precursor protein is nuclear mitotic apparatus protein 1 (NUMA1), a protein that plays an essential role in the formation and maintenance of the spindle poles and the alignment and the segregation of chromosomes during mitotic cell division. PDHPS1 binds to protein phosphatase 2 phosphatase activator (PTPA), an essential activator of protein phosphatase 2A (PP2A), increasing phosphorylation of the oncogene Yes-associated protein (YAP), further inactivating YAP and suppressing the expression of its downstream target genes. PDHPS1 inhibits the proliferation of ovarian cancer cells in vitro, induces cell apoptosis in ovarian cancer cells and inhibits ovarian tumour growth in a subcutaneous xenograft mouse model.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• Pan et al (2022) Peptide PDHPS1 Inhibits Ovarian Cancer Growth through Disrupting YAP Signaling. Mol Cancer Ther. 21(7) 1160 PMID: 35545004

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.