PD-L205/PD-L2 16-25 peptide

PD-L205/PD-L2 16-25 peptide

• COA/MS/HPLC Report
• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

H-QIAALFTVTV-OH

H-Gln-Ile-Ala-Ala-Leu-Phe-Thr-Val-Thr-Val-OH

10

95.21%

C₅₀H₈₃N₁₁O₁₄

1062.26

Synthetic

Powder

PD-L205 (PD-L2 16-25) appeared to be the dominant epitope for eliciting immune responses. It elicited the strongest response that was equivalent to a potent HLA-A2-restricted epitope in PD-L1. PD-L1-specific and PD-L2-specific T cells did not cross-react. PD-L2-specific T cells reacted to autologous target cells depending on PD-L2 expression. Activating PD-L2 specific T cells (e.g., by vaccination) might be an attractive strategy for anti-cancer immunology.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• Ahmad SM, Martinenaite E, Holmström M, Jørgensen MA, Met Ö, Nastasi C, Klausen U, Donia M, Pedersen LM, Munksgaard L, Ødum N, Woetmann A, Svane IM, Andersen MH. The inhibitory checkpoint, PD-L2, is a target for effector T cells: Novel possibilities for immune therapy. Oncoimmunology. 2017 Nov 1;7(2):e1390641. doi: 10.1080/2162402X.2017.1390641. PMID: 29308318; PMCID: PMC5749669.

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.