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  • Papiliocin Pap12-6 peptide

Papiliocin Pap12-6 peptide

Not For Human Use, Lab Use Only.

Cat.#: 318868

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* Buy 1 get 1 free (?) What is TFA?

Special Price 104.00 USD

Availability: 1-2 weeks
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Product Information

  • Product Name
    Papiliocin Pap12-6 peptide
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    H-RWKIFKKVVKKW-NH2
  • Sequence
    H-Arg-Trp-Lys-Ile-Phe-Lys-Lys-Val-Val-Lys-Lys-Trp-NH2
  • Length (aa)
    12
  • Peptide Purity (HPLC)
    95.2%
  • Molecular Formula
    C83H133N23O12
  • Molecular Weight
    1645.09
  • Source
    Synthetic
  • Form
    Powder
  • Description
    A short, 12-meric antimicrobial peptide, Pap12-6, was designed by substituting amino acids from the N-terminal 12 residues of papiliocin (Pap12-1) to alter cationicity and amphipathicity. Pap12-6 exhibits broad-spectrum antibacterial activity, particularly against multidrug-resistant Gram-negative bacteria. It kills bacteria by permeabilizing the bacterial membrane, as demonstrated by dye leakage, membrane depolarization, and electron microscopy. Pap12-6 also reduces secretion of NO, TNF-α, and IL-6, showing anti-inflammatory activity via a TLR4-mediated NF-κB signaling pathway.
  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • Kim J, Jacob B, Jang M, Kwak C, Lee Y, Son K, Lee S, Jung ID, Jeong MS, Kwon SH, Kim Y. Development of a novel short 12-meric papiliocin-derived peptide that is effective against Gram-negative sepsis. Sci Rep. 2019 Mar 7;9(1):3817.
  • About TFA salt

    Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

    Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

    Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

    In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

  • Molar Concentration Calculator

  • Dilution Calculator

  • Percent Concentration Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Volume
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Molecular Weight

Peptide Property

  • Analysed Sequence:A
  • Chemical Formula:A
  • Sequence length:A
  • Extinction coefficient:A M-1cm-1
  • GRAVY:A
  • Mw average:A
  • Theoretical pI:A
  • Data Source:Peptide Property Calculator

GRAVY = grand average of hydropathy

X: Hydrophobic uncharged residues, like F I L M V W A and P

X: Basic residues, like R K H

X: Acidic residues, like D E

X: Polar uncharged residues, like G S T C N Q and Y

• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"