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  • Palmitoyl pentapeptide 4

Palmitoyl pentapeptide 4

Not For Human Use, Lab Use Only.

Cat.#: 319821

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* Buy 1 get 1 free (?) What is TFA?

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Product Information

  • Product Name
    Palmitoyl pentapeptide 4
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    Palmitoyl-KTTKS-OH
  • Sequence
    Palmitoyl-Lys-Thr-Thr-Lys-Ser-OH
  • Length (aa)
    5
  • Peptide Purity (HPLC)
    95.29%
  • Molecular Formula
    C39H75N7O10
  • Molecular Weight
    802.05
  • CAS No.
    214047-00-4
  • Source
    Synthetic
  • Form
    Powder
  • Description

    Palmitoyl pentapeptide-4, also known as Pal-KTTKS or Matrixyl, is a synthetic lipopeptide composed of five amino acid residues (Lys-Thr-Thr-Lys-Ser) linked to a palmitoyl group. This structural modification enhances its stability and skin permeability. The peptide functions as a fragment of procollagen type I, acting as a signaling molecule that stimulates extracellular matrix (ECM) components. In vitro studies demonstrate its ability to upregulate the production of collagen types I, III, and IV, fibronectin, and glycosaminoglycans in dermal fibroblasts.

    Biophysical analyses reveal that palmitoyl pentapeptide-4 modulates dermal restructuring through a feedback mechanism. When incorporated into sparse ECM environments, it triggers cellular responses that inhibit collagen degradation while promoting ECM synthesis. The presence of proline residues facilitates hydroxylation, a critical process for collagen maturation. These molecular interactions contribute to measurable improvements in skin elasticity and surface topography, as quantified by parameters such as viscoelasticity and trans-epidermal water loss.

  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • Suhendra N N. The efficacy of 7% palmitoyl pentapeptide-4 serum for the periorbital wrinkle reduction[C]//Rangsit Graduate Research Conference: RGRC. 2020, 15(2563)): 2870-2884.
  • About TFA salt

    Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

    Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

    Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

    In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

  • Molar Concentration Calculator

  • Dilution Calculator

  • Percent Concentration Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"