Pal-KTTKS peptide

Pal-KTTKS peptide

• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

Palmitoyl-KTTKS-OH

Palmitoyl-Lys-Thr-Thr-Lys-Ser-OH

5

95.25%

C₃₉H₇₅N₇O₁₀

802.05

Synthetic

Powder

Pal-KTTKS, a lipidated subfragment of type 1 pro-collagen (residues 212–216), plays a role in fibroblast contractility. Pal-KTTKS reduces α-SMA expression and trans-differentiation of fibroblasts to myofibroblast. KTTKS is a small, highly specific biologically active peptide which has been reported to produce stimulation of elastin and collagens, specifically types I and III.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• Park H, An E, Cho Lee AR. Effect of Palmitoyl-Pentapeptide (Pal-KTTKS) on Wound Contractile Process in Relation with Connective Tissue Growth Factor and α-Smooth Muscle Actin Expression. Tissue Eng Regen Med. 2017 Jan 19;14(1):73-80. doi: 10.1007/s13770-016-0017-y. PMID: 30603464; PMCID: PMC6171572.
• Abu Samah NH, Heard CM. Topically applied KTTKS: a review. Int J Cosmet Sci. 2011 Dec;33(6):483-90. doi: 10.1111/j.1468-2494.2011.00657.x. Epub 2011 May 3. PMID: 21535443.

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.