P144 peptide

P144 peptide

• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

H-TSLDASIIWAMMQN-OH

H-Thr-Ser-Leu-Asp-Ala-Ser-Ile-Ile-Trp-Ala-Met-Met-Gln-Asn-OH

14

95.18%

C₆₈H₁₀₉N₁₇O₂₂S₂

1580.81

Synthetic

Powder

P144 (TSLDASIIWAMMQN), a hydrophobic peptide derived from the sequence of the extracellular region of type III receptor for TGF-β (Betaglycan, amino acids 730–743). P144 reduces early CNV progression in a laser-induced rat model. This is achieved through downregulation of VEGF and TGF-β, but also by affecting other mediators involved in the angiogenic process, such as COX-2, MMP-2 and MMP-9. P144 may have an antiangiogenic role in CNV treatment affecting the main target of current treatments through TGF-β inhibition.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• Zarranz-Ventura J, Fernández-Robredo P, Recalde S, Salinas-Alamán A, Borrás-Cuesta F, Dotor J, García-Layana A. Transforming growth factor-beta inhibition reduces progression of early choroidal neovascularization lesions in rats: P17 and P144 peptides. PLoS One. 2013 May 31;8(5):e65434. doi: 10.1371/journal.pone.0065434. PMID: 23741494; PMCID: PMC3669249.

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.