Recombinant OLIG3 protein (His tag)

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Recombinant Human Oligodendrocyte Transcription Factor 3 (Oligo3) Fragment (aa 76-154) is a high-purity protein designed for functional studies of the bHLH domain. This fragment enables targeted investigation into neuronal specification mechanisms in the dorsal spinal cord, offering researchers a precise tool for domain-specific analysis.

Oligodendrocyte Transcription Factor 3 (OLIG3) is a class B basic helix-loop-helix protein that plays a critical role in neuronal patterning within the dorsal spinal cord. According to functional studies, OLIG3 helps determine the distinct specification program of class A neurons while simultaneously suppressing the specification of class B neurons, thereby establishing crucial neuronal diversity in this region. The protein localizes to the nucleus, consistent with its function as a transcription factor. The provided fragment (amino acids 76-154) contains the complete bHLH functional domain (aa 83-137), which is essential for DNA binding and protein dimerization, making it particularly valuable for studying the molecular mechanisms underlying neuronal fate determination.