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Recombinant OGA protein (His tag)

Cat.#: 537256

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Product Information

  • Product Name
    Recombinant OGA protein (His tag)
  • Documents
  • Description

    Recombinant Human Protein O-GlcNAcase (OGA) Fragment (60-336) is a high-purity, enzymatically active protein designed for studying O-GlcNAc hydrolysis. This fragment encompasses the full GH84 domain, offering researchers a precise tool to investigate O-GlcNAcase function, substrate specificity, and regulatory mechanisms in cellular signaling pathways.

    Protein O-GlcNAcase (OGA) is a key enzyme in human cells that selectively cleaves O-linked N-acetylglucosamine (GlcNAc) modifications from serine and threonine residues of proteins. It plays a crucial role in regulating diverse cellular processes by deglycosylating numerous substrates, including CRYAB, ELK1, GSDMD, LMNB1, and TAB1, thereby influencing protein stability, activity, and localization. Isoform 1, the primary cytoplasmic form, exhibits strict substrate specificity for beta-GlcNAc and does not possess acetyltransferase activity. O-GlcNAcylation is a dynamic post-translational modification involved in nutrient sensing, stress response, and gene

  • Protein name
    Protein O-GlcNAcase
  • Uniprot ID
    O60502
  • Gene Name
    OGA; HEXC; KIAA0679; MEA5; MGEA5
  • Source/Expression Host
    E. coli
  • Expression Plasmid/cDNA
    DNA encoding 60-336 aa (O60502) were fused with N-terminal 6His tag.
  • Sequence 
    MNHKVHHHHH HGGSFLCGVV EGFYGRPWVM EQRKELFRRL QKWELNTYLY APKDDYKHRM FWREMYSVEE AEQLMTLISA
AREYEIEFIY AISPGLDITF SNPKEVSTLK RKLDQVSQFG CRSFALLFDD IDHNMCAADK EVFSSFAHAQ VSITNEIYQY
LGEPETFLFC PTEYCGTFCY PNVSQSPYLR TVGEKLLPGI EVLWTGPKVV SKEIPVESIE EVSKIIKRAP VIWDNIHAND
YDQKRLFLGP YKGRSTELIP RLKGVLTNPN CEFEANYVAI HTLATWYKSN M
  • Protein Species
    Human
  • Molecular weight
    Predictes a molecular mass of 33.93 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 35 kDa band.
  • Purity
    >85%, by SDS-PAGE with Coomassie Brilliant Blue staining.
  • Activity
    Not tested.
  • Validations

    Recombinant OGA protein (His tag) SDS-PAGE

    Recombinant OGA protein (His tag) SDS-PAGE

    M: Marker; Lane 1: OGA; Lane 2: BSA

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"