NYZL1 peptide

NYZL1 peptide

• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

H-CSSPIGRHC-OH

H-Cys-Ser-Ser-Pro-Ile-Gly-Arg-His-Cys-OH

9

95.83%

C₃₇H₆₂N₁₄O₁₂S₂

959.1

Synthetic

Powder

NYZL1, with strong tumor‑homing ability, was identified by in vivo phage library selection in the bladder cancer model. The NYZL1 phage and synthetic FITC-labeled NYZL1 peptides bound to tumor tissues and cells, but were hardly detected in normal control organs. Notably, accumulation of FITC-NYZL1 in bladder tumor cells was time-dependent. Biodistribution studies of xenografts of BIU-87 cells showed accumulation of injected FITC-NYZL1 in the tumors, and the bound peptide could not be removed by perfusion after 24 h. NYZL1 may represent a lead peptide structure applicable in the development of optical molecular imaging.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• Yang, X., Zhang, F., Luo, J., Pang, J., Yan, S., Luo, F. ... Su, X. (2016). A new non-muscle-invasive bladder tumor-homing peptide identified by phage display in vivo . Oncology Reports, 36, 79-89. https://doi.org/10.3892/or.2016.4829

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.