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Product Name
Recombinant NU205 protein (His tag)
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Description
This recombinant protein is a 171-amino acid fragment (residues 1181-1351) of the human Nuclear Pore Complex Protein Nup205, a key component of the nuclear pore complex (NPC). Designed for structural and biochemical studies, this fragment offers a stable and soluble unit ideal for investigating NPC assembly, nucleoporin anchoring, and nuclear transport mechanisms.
Nuclear Pore Complex Protein Nup205 (NUP205) is a 205 kDa nucleoporin essential for NPC assembly and maintenance. It functions by anchoring specific nucleoporins, such as NUP62, to the NPC while also collaborating with TMEM209 to facilitate nuclear transport of proteins, including MYC. Located at the nucleus membrane as a peripheral membrane protein, Nup205 is integral to the NPC core structure, positioned centrally on both cytoplasmic and nuclear sides, underscoring its critical role in nucleocytoplasmic transport and cellular regulation.
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Protein name
Nuclear pore complex protein Nup205
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Uniprot ID
Q92621
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Gene Name
NUP205; C7orf14; KIAA0225
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 1181-1351 aa (Q92621) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 20.94 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 21 kDa band.
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Purity
>87%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"