Recombinant NRG1 protein (His tag)

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Recombinant Human Pro-Neuregulin-1 (NRG1) Fragment (aa 37-133) is a high-purity protein designed for targeted research applications. This fragment encompasses the Ig-like C2-type domain, offering a precise tool for investigating domain-specific functions in cell signaling, differentiation, and receptor interactions.

Pro-Neuregulin-1 (Pro-NRG1) is a membrane-bound protein in Homo sapiens that acts as a direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. It recruits ERBB1 and ERBB2 coreceptors, leading to tyrosine phosphorylation and activation of ERBB signaling pathways. The protein plays critical roles in growth and differentiation across epithelial, glial, neuronal, and skeletal muscle cells, and is involved in acetylcholine receptor expression at neuromuscular junctions, mammary gland development, Schwann cell proliferation, and myocardial trabeculation. Isoforms also bind integrins (e.g., ITGAV:ITGB3 or ITGA6:ITGB4), forming ternary complexes essential for NRG1-ERBB signaling, and activate kinases like MAPK3/ERK1, MAPK1/ERK2, and AKT1. Subcellular localization varies by isoform: the full-length membrane-bound form is a single-pass type I membrane protein, while cleaved Neuregulin-1 is secreted, and certain isoforms may localize to the nucleus or possess internal signal sequences.