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Product Name
NP213 (Novexatin) peptide (TFA removed)
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Documents
Batch to batch variation of the purity
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Sequence Shortening
cyclo[RRRRRRR]
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Sequence
cyclo[Arg-Arg-Arg-Arg-Arg-Arg-Arg]
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Length (aa)
7
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Peptide Purity (HPLC)
95.7%
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Molecular Formula
C42H84N28O7
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Molecular Weight
1093.3
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CAS No.
942577-31-3
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PubChem CID
16679727
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Source
Synthetic
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Form
Powder
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Description
NP213, a novel, first-in-class synthetic antimicrobial peptide (AMP), exhibits rapid antifungal activity. It targets the fungal cytoplasmic membrane, disrupting its integrity through membrane perturbation and disruption. NP213 has demonstrated efficacy and tolerability in resolving nail fungal infections. Its unique mode of action makes it a promising therapeutic option for combating fungal infections.
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Storage Guidelines
Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual:Handling and Storage of Synthetic Peptides
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References
- Correction to: NP213 (Novexatin): A unique therapy candidate for onychomycosis with a differentiated safety and efficacy profile. Med Mycol. 2023;61(8):myad088. doi:10.1093/mmy/myad088
- Mercer DK, Robertson JC, Miller L, Stewart CS, O'Neil DA. NP213 (Novexatin®): A unique therapy candidate for onychomycosis with a differentiated safety and efficacy profile [published correction appears in Med Mycol. 2023 Aug 2;61(8):]. Med Mycol. 2020;58(8):1064-1072. doi:10.1093/mmy/myaa015
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About TFA salt
Trifluoroacetic acid (TFA) has a significant impact on peptides due to its role in the peptide synthesis process.
TFA is essential for the protonation of peptides that lack basic amino acids such as Arginine (Arg), Histidine (His), and Lysine (Lys), or ones that have blocked N-termini. As a result, peptides often contain TFA salts in the final product.
TFA residues, when present in custom peptides, can cause unpredictable fluctuations in experimental data. At a nanomolar (nM) level, TFA can influence cell experiments, hindering cell growth at low concentrations (as low as 10 nM) and promoting it at higher doses (0.5–7.0 mM). It can also serve as an allosteric regulator on the GlyR of glycine receptors, thereby increasing receptor activity at lower glycine concentrations.
In an in vivo setting, TFA can trifluoroacetylate amino groups in proteins and phospholipids, inducing potentially unwanted antibody responses. Moreover, TFA can impact structure studies as it affects spectrum absorption.
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Molar Concentration Calculator
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Dilution Calculator
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Percent Concentration Calculator
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
Related Products / Services
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• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"