Recombinant NLRP3 protein (His tag)

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Recombinant Human NLRP3 Pyrin Domain Fragment (residues 1-94) – a high-purity protein fragment ideal for investigating the molecular mechanisms of inflammasome activation and inflammatory signaling pathways. This precisely engineered fragment contains the complete Pyrin functional domain, enabling targeted studies of NLRP3's role in innate immunity and autoinflammatory diseases.

NLRP3 (NACHT, LRR and PYD domains-containing protein 3) serves as the critical sensor component of the NLRP3 inflammasome, which activates in response to membrane integrity defects and various damage-associated signals. This activation leads to caspase-1-mediated processing and secretion of pro-inflammatory cytokines IL-1β and IL-18, induction of pyroptosis through gasdermin-D cleavage, and HMGB1 secretion. The full-length protein localizes to multiple subcellular compartments including cytoplasm, microtubule organizing centers, and Golgi membranes, where it forms active inflammasome complexes upon stimulation. The Pyrin domain (residues 1-93) contained within this fragment mediates essential protein-protein interactions during inflammasome assembly, making it invaluable for structural studies, interaction mapping, and functional characterization of NLRP3-mediated inflammatory responses.