Recombinant NFKB2 protein (His tag)

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Recombinant Human NF-kappa-B p100 Subunit Fragment (437-848) – a high-quality protein fragment derived from the Nuclear factor NF-kappa-B p100 subunit (NFKB2), designed for structural and biochemical studies. This 412-amino acid fragment offers a stable and soluble unit ideal for investigating NF-kappa-B signaling pathways, inflammation, immunity, and transcriptional regulation.

NF-kappa-B is a pleiotropic transcription factor central to numerous biological processes, including inflammation, immunity, cell growth, differentiation, tumorigenesis, and apoptosis. It functions as a homo- or heterodimeric complex, with NFKB2/p100 undergoing proteolytic processing to generate the p52 subunit, which forms active transcriptional complexes (e.g., with RelB) or repressive homodimers. The full-length protein is involved in both canonical and non-canonical NF-kappa-B activation pathways, regulating gene expression by binding kappa-B sites in DNA. It localizes to the nucleus and cytoplasm, where it remains inactive when complexed with inhibitors like I-kappa-B, and plays a role in circadian clock regulation by repressing CLOCK-BMAL1 activity. This recombinant fragment (437-848) provides a focused tool for exploring these mechanisms without the complexities of the full-length protein.