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  • Neuropeptide VF (124-131) (human)

Neuropeptide VF (124-131) (human)

Not For Human Use, Lab Use Only.

Cat.#: 310317

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Product Information

  • Product Name
    Neuropeptide VF (124-131) (human)
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    VPNLPQRF-NH2
  • Sequence
    H-Val-Pro-Asn-Leu-Pro-Gln-Arg-Phe-NH2
  • Length (aa)
    8
  • Peptide Purity (HPLC)
    99.92%
  • Molecular Formula
    C45H72N14O10
  • Molecular Weight
    969.13
  • Source
    Synthetic
  • Form
    Powder
  • Description
    Neuropeptide VF (NPVF, VPNLPQRF-NH₂) is an eight-amino-acid neuropeptide secreted by the human hypothalamus. It belongs to the NPFF neuropeptide family and is a highly selective ligand of NPFFR1, a Gi/o protein-coupled receptor located in the nervous system. NPVF plays a significant role in bone regeneration. In vitro studies have shown that it can promote the migration and angiogenesis of human umbilical vein endothelial cells (HUVECs). It activates NPFFR1, leading to the upregulation of miR-181c-3p and downregulation of Argonaute1 (AGO1), which in turn promotes cell migration and angiogenesis. Additionally, NPVF mediates the osteogenic differentiation of bone mesenchymal stem cells (BMSCs) via the Wnt/β-catenin signaling pathway.
  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • Q.Liu et al., J. Biol. Chem., 276, 36961 (2001).
    • Yu, H., Wang, Y., Gao, J. et al. Application of the neuropeptide NPVF to enhance angiogenesis and osteogenesis in bone regeneration. Commun Biol 6, 197 (2023).
  • About TFA salt

    Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

    Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

    Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

    In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

  • Molar Concentration Calculator

  • Dilution Calculator

  • Percent Concentration Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Volume
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Molecular Weight

Peptide Property

  • Analysed Sequence:A
  • Chemical Formula:A
  • Sequence length:A
  • Extinction coefficient:A M-1cm-1
  • GRAVY:A
  • Mw average:A
  • Theoretical pI:A
  • Data Source:Peptide Property Calculator

GRAVY = grand average of hydropathy

X: Hydrophobic uncharged residues, like F I L M V W A and P

X: Basic residues, like R K H

X: Acidic residues, like D E

X: Polar uncharged residues, like G S T C N Q and Y

• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"