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  • Neuropeptide GE (Glycine-Glutamic acid)

Neuropeptide GE (Glycine-Glutamic acid)

Not For Human Use, Lab Use Only.

Cat.#: 306416

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Product Information

  • Product Name
    Neuropeptide GE (Glycine-Glutamic acid)
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    GSVAFPAENGVQNTESTQE
  • Sequence
    H-Gly-Ser-Val-Ala-Phe-Pro-Ala-Glu-Asn-Gly-Val-Gln-Asn-Thr-Glu-Ser-Thr-Gln-Glu-OH
  • Length (aa)
    19
  • Peptide Purity (HPLC)
    97%
  • Molecular Formula
    C81H125N23O34
  • Molecular Weight
    1965.02
  • CAS No.
    134748-04-2
  • Source
    Synthetic
  • Form
    Powder
  • Description

    Neuropeptide G-E (NGE) is a neuropeptide derived from the melanin-concentrating hormone (MCH) precursor. Along with MCH and neuropeptide E-I (NEI), NGE is processed from the same prohormone and is implicated in various neural activities. Studies indicate that at relatively high concentrations, NGE can activate the melanocortin MC1 receptor, leading to downstream signaling events such as cAMP formation and stimulation of melanin synthesis in pigment cells. This interaction suggests a potential cross-reactivity between the MCH and melanocortin systems, particularly in contexts where local peptide concentrations are elevated, such as in autocrine or paracrine signaling mechanisms.

  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • J.Cardot et al., Gen. Comp. Endocrinol., 94, 23 (1994)
    • Hintermann E, Tanner H, Talke-Messerer C, Schlumberger S, Zumsteg U, Eberle AN. Interaction of melanin-concentrating hormone (MCH), neuropeptide E-I (NEI), neuropeptide G-E (NGE), and alpha-MSH with melanocortin and MCH receptors on mouse B16 melanoma cells. J Recept Signal Transduct Res. 2001 Feb;21(1):93-116. doi: 10.1081/rrs-100107145. PMID: 11693176.
  • About TFA salt

    Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

    Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

    Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

    In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

  • Molar Concentration Calculator

  • Dilution Calculator

  • Percent Concentration Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"