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Product Name
Recombinant NEK4 protein (His tag)
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Description
Recombinant Human Serine/threonine-protein kinase Nek4 (NEK4) fragment (amino acids 1-274), encompassing the full protein kinase domain. This high-purity, functional fragment is an essential tool for investigating kinase activity, DNA damage response, and cellular senescence mechanisms in life science research.
Serine/threonine-protein kinase Nek4 (NEK4) is a crucial regulatory enzyme that phosphorylates threonine residues and plays key roles in cellular homeostasis. It is required for normal replicative senescence, enabling proliferative arrest after limited cell divisions, and is essential for proper cell cycle arrest in response to double-stranded DNA damage. Localized to both the cytoplasm and cell projections such as cilia, Nek4 functions in critical signaling pathways that maintain genomic integrity and control cellular aging processes, making it a significant target for cancer and aging-related research.
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Protein name
Serine/threonine-protein kinase Nek4
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Uniprot ID
P51957
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Gene Name
NEK4; STK2
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 1-274 aa (P51957) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 33.35 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 33 kDa band.
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Purity
>90%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"