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  • NDC80 HLA-A*02/ALNEQIARL peptide

NDC80 HLA-A*02/ALNEQIARL peptide

Not For Human Use, Lab Use Only.

Cat.#: 319310

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* Buy 1 get 1 free (?) What is TFA?

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Product Information

  • Product Name
    NDC80 HLA-A*02/ALNEQIARL peptide
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    H-ALNEQIARL-OH
  • Sequence
    H-Ala-Leu-Asn-Glu-Gln-Ile-Ala-Arg-Leu-OH
  • Length (aa)
    9
  • Peptide Purity (HPLC)
    95.98%
  • Molecular Formula
    C44H78N14O14
  • Molecular Weight
    1027.17
  • Source
    Synthetic
  • Form
    Powder
  • Description
    ALNEQIARL is a HLA-A*02 restricted peptide from the kinetochore-associated NDC80 gene. HLA-A*02 is the most prevalent and polymorphic major histocompatibility complex (MHC) allele family in humans. CAR T cells directed against the ALNEQIARL:HLA-A*02 complex exhibited high sensitivity and specificity for recognition and killing of multiple cancer types, especially those of hematologic origin, and were efficacious in mouse models against a human leukemia and a solid tumor.
  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • Klatt MG, Dao T, Yang Z, Liu J, Mun SS, Dacek MM, Luo H, Gardner TJ, Bourne C, Peraro L, Aretz ZEH, Korontsvit T, Lau M, Kharas MG, Liu C, Scheinberg DA. A TCR mimic CAR T cell specific for NDC80 is broadly reactive with solid tumors and hematologic malignancies. Blood. 2022 Aug 25;140(8):861-874. doi: 10.1182/blood.2021012882. PMID: 35427421; PMCID: PMC9412008.
  • About TFA salt

    Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

    Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

    Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

    In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

  • Molar Concentration Calculator

  • Dilution Calculator

  • Percent Concentration Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"