Nal-P-113 peptide

Nal-P-113 peptide

• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

AKR-Nal-Nal-GYKRKF-Nal, Nal=β-naphthylalanine, 1-Nal

12

96.2%

1745.13

Synthetic

Powder

Nal-P-113, a modified version of antimicrobial peptide P-113, its amino sequence is AKR-Nal-Nal-GYKRKF-Nal-NH2. Antimicrobial peptide P-113 showed promising antimicrobial effects against a variety of pathogens. Compared to P-113, Nal-P-113 maintained its effects when exposed to a high salt concentration and therefore it was an ideal candidate for application in complicated matrices including oral cavity, serum and plasma. Nal-P-113 exerts its anti-bactericidal effects in a rat periodontitis model with a significant reduction in tissue inflammation. Nal-P-113 inhibits Porphyromonas gingivalis (P. gingivalis) W83 biofilms formation.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• Wang HY, Lin L, Tan LS, Yu HY, Cheng JW, Pan YP. Molecular pathways underlying inhibitory effect of antimicrobial peptide Nal-P-113 on bacteria biofilms formation of Porphyromonas gingivalis W83 by DNA microarray. BMC Microbiol. 2017 Feb 17;17(1):37.

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.