Myxinidin peptide

Myxinidin peptide

• COA/MS/HPLC Report
• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

GIHDILKYGKPS

H-Gly-Ile-His-Asp-Ile-Leu-Lys-Tyr-Gly-Lys-Pro-Ser-OH

12

96.9%

C₆₁H₉₈N₁₆O₁₇

1327.54

Synthetic

Powder

Screened pathogens, including S. enterica serovar Typhimurium C610, E. coli D31, A. salmonicida A449, Y. ruckeri 96-4, and L. anguillarum 02-11, are highly sensitive to myxinidin at the MBC of 1.0-2.5 ug/mL. Myxinidin exhibits antimicrobial activity two to 16 times more active than pleurocidin (NRC-17) against most pathogens. Its microbicidal activity is retained in the presence of NaCl up to 0.3 M and shows no hemolytic activity against mammalian red blood cells. Myxinidin has a helical structure (residues 2-8) with the C-terminal 4 residues GKPS disordered. Optimized antibacterial activity is achieved by adding Trp at the N terminus and substituting residues at positions 3, 4, and 11 with arginine. Myxinidin exhibits antibacterial and antifungal activity and is sourced from epidermal mucus of Myxine glutinosa L..

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• Lombardi L, Shi Y, Falanga A, Galdiero E, de Alteriis E, Franci G, Chourpa I, Azevedo HS, Galdiero S. Enhancing the Potency of Antimicrobial Peptides through Molecular Engineering and Self-Assembly. Biomacromolecules. 2019 Mar 11;20(3):1362-1374.

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.