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  • Myostatin inhibitory peptide 3d

Myostatin inhibitory peptide 3d

Cat.#: 318721

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Optional Service: TFA RemovalWhat's this?

Special Price 271.0 USD

Availability: 3 weeks
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Product Information

  • Product Name
    Myostatin inhibitory peptide 3d
  • Documents
  • Quantity/Unit
    1 Vial
  • Sequence
    XRQNTRYSRIEWIKIQIISKLRL-amide (X = 2-naphthoxyacetyl group)
  • Length (aa)
    23
  • Peptide Purity (HPLC)
    95.8
  • Molecular Formula
    C139H225N41O33
  • Molecular Weight
    2998.57
  • Source
    Synthetic
  • Additional Information
    Myostatin, a negative regulator of skeletal muscle growth, is a promising target for treating muscle atrophic disorders. A novel peptide myostatin inhibitory peptide 3d displayed an IC50 value of 0.32 μM, which is 11 times more potent than peptide(WRQNTRYSRIEAIKIQILSKLRL-amide). The peptide 3d would have the potential to be a promising drug lead to develop better peptidomimetics.
  • Storage Guidelines
    Ideally Myostatin inhibitory peptide 3d should be stored in a freezer at or below -9C. Myostatin inhibitory peptide 3d should be refrigerated after reconstitution. For more details, please refer to the manual:Handling and Storage of Synthetic Peptides
  • References
    • Takayama K, Rentier C, Asari T, et al. Development of Potent Myostatin Inhibitory Peptides through Hydrophobic Residue-Directed Structural Modification. ACS Med Chem Lett. 2017;8(7):751-756
  • About TFA salt

    Trifluoroacetic acid (TFA) is a strong acid, which is commonly used to cleave synthesized peptides from solid-phase resins and is also used to improve HPLC performance in the peptide purification step. By default, custom peptides are delivered as lyophilized TFA salts, and can contain as much as 10-45% TFA.

    TFA in custom peptides can cause inexplicable discrepancies in subsequent assay data. For instance, TFA in nM concentrations has been shown to interfere with cellular assays, inhibiting cellular proliferation in some instances, and increasing cell viability in others . It has also been found to be an unintended allosteric modulator of the glycine receptor, GlyR.

    TFA Removal Service is recommended for:

    • Peptides that will be used in cellular assays
    • Peptides that will be used as APIs or in manufactured products
    • For hydrophilic peptides containing numerous basic residues

Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"