Recombinant MTMR3 protein (His tag)

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This recombinant protein product features a stable and soluble fragment (residues 310-578) of human Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR3, a key lipid phosphatase involved in phosphoinositide signaling and membrane trafficking regulation. The fragment is optimized for structural and biochemical studies, providing researchers with a reliable tool to investigate MTMR3's enzymatic and regulatory functions.

MTMR3 (Myotubularin-related protein 3) is a lipid phosphatase that specifically dephosphorylates phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate at the D-3 position, generating phosphatidylinositol and phosphatidylinositol 5-phosphate. By modulating levels of phosphatidylinositol 3-phosphate—a crucial regulator of cell signaling and intracellular membrane traffic—MTMR3 plays a vital role in cellular homeostasis. Beyond its phosphatase activity, MTMR3 may function as a molecular adapter, independently regulating processes such as midbody abscission during mitotic cytokinesis. The protein localizes to the cytoplasm, cytosol, and membranes as a peripheral membrane protein, underscoring its involvement in membrane-associated signaling pathways.