Recombinant MSRA protein (His tag)

• DataSheet
• Material Safety Data Sheets (MSDS)

This recombinant protein product features a stable and soluble fragment (residues 24-235) of human Mitochondrial peptide methionine sulfoxide reductase (MSRA). This carefully selected fragment retains the enzyme's core methionine sulfoxide reductase activity, making it an ideal tool for studying oxidative damage repair mechanisms in proteins.

Mitochondrial peptide methionine sulfoxide reductase (MSRA) serves as a critical repair enzyme that reverses oxidative damage to proteins by catalyzing the reduction of methionine sulfoxide back to methionine. This function is essential for maintaining protein integrity under oxidative stress conditions. The full-length protein exhibits distinct subcellular localization patterns across its isoforms: isoform 1 localizes to mitochondria, isoforms 2 and 3 are found in the cytoplasm (with isoform 3 also nuclear), while isoform 5 associates with membranes via lipid anchoring. These diverse localization patterns suggest compartment-specific roles in oxidative damage repair throughout the cell.