-
Product Name
Recombinant MRM1 protein (His tag)
- Documents
-
Description
This product is a recombinant fragment of human rRNA methyltransferase 1, mitochondrial (MRM1), spanning residues 49-310. It represents a stable and soluble unit of the enzyme, ideal for structural and biochemical studies, particularly those investigating its role in ribosomal RNA modification.
The full-length MRM1 protein is an S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that specifically catalyzes the formation of 2'-O-methylguanosine at position 1145 (Gm1145) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA). This modification is universally conserved in the peptidyl transferase domain of the mtLSU rRNA, highlighting its fundamental role in mitochondrial ribosome function and protein synthesis. MRM1 is localized to the mitochondrial matrix, where it performs its essential enzymatic activity in mitochondrial gene expression.
-
Protein name
rRNA methyltransferase 1, mitochondrial
-
Uniprot ID
Q6IN84
-
Gene Name
MRM1
-
Source/Expression Host
E. coli
-
Expression Plasmid/cDNA
DNA encoding 49-310 aa (Q6IN84) were fused with 6His tag.
-
Protein Species
Human
-
Molecular weight
Predictes a molecular mass of 30.29 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 30 kDa band.
-
Purity
>89%, by SDS-PAGE with Coomassie Brilliant Blue staining.
-
Activity
Not tested.
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"