Mouse MOG (35-55) peptide

Mouse MOG (35-55) peptide

• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

H-MEVGWYRSPFSRVVHLYRNGK-OH

H-Met-Glu-Val-Gly-Trp-Tyr-Arg-Ser-Pro-Phe-Ser-Arg-Val-Val-His-Leu-Tyr-Arg-Asn-Gly-Lys-OH

21

95.36%

C₁₁₈H₁₇₇N₃₅O₂₉S

2581.94

Synthetic

Powder

Myelin oligodendrocyte glycoprotein (MOG) 35-55, MEVGWYRSPFSRVVHLYRNGK, a minor component of CNS myelin, is a member of the immunoglobulin superfamily. It is expressed in central nervous system myelin which produces a relapsing-remitting neurological diesease with extensive plague-like demyelination. MOG 35-55 peptide is an immunodominant epitope of MOG that induces strong T and B cell responses and Induces experimental autoimmune encephalomyelitis in rodents. Cysteine containing MOG (35-55) peptide can induce polyclonal anti-MOG(35-55) antibody production in rabbits with high specificity. Immunization with MOG (35-55) suppresses spontaneous regeneration of dopaminergic neurons injured with MPTP.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• Manouchehri N, Salinas VH, Hussain RZ, Stüve O. Distinctive transcriptomic and epigenomic signatures of bone marrow-derived myeloid cells and microglia in CNS autoimmunity. Proc Natl Acad Sci U S A. 2023 Feb 7;120(6):e2212696120. doi: 10.1073/pnas.2212696120. Epub 2023 Feb 2. PMID: 36730207; PMCID: PMC9963604.

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.