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Product Name
Recombinant MND1 protein (His tag)
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Description
Recombinant Human Meiotic Nuclear Division Protein 1 Homolog (MND1) Fragment (aa 2-205) is a high-quality protein product designed for structural and biochemical studies. This stable and soluble fragment, derived from the MND1 gene, retains key functional regions essential for investigating homologous recombination and chromosome pairing mechanisms in meiosis.
The full-length Meiotic Nuclear Division Protein 1 Homolog (MND1) is a nuclear protein crucial for proper homologous chromosome pairing and efficient crossover events during meiosis. It functions by stimulating both DMC1- and RAD51-mediated homologous strand assimilation, which is necessary for resolving meiotic double-strand breaks, thereby supporting accurate genetic recombination. This protein's role in promoting homologous recombination underscores its importance in maintaining genomic stability during gametogenesis.
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Protein name
Meiotic nuclear division protein 1 homolog
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Uniprot ID
Q9BWT6
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Gene Name
MND1; GAJ
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 2-205 aa (Q9BWT6) were fused with C-terminal 6His tag.
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Sequence
MSKKKGLSAE EKRTRMMEIF SETKDVFQLK DLEKIAPKEK GITAMSVKEV LQSLVDDGMV DCERIGTSNY YWAFPSKALH ARKHKLEVLE SQLSEGSQKH ASLQKSIEKA KIGRCETEER TRLAKELSSL RDQREQLKAE VEKYKDCDPQ VVEEIRQANK VAKEAANRWT DNIFAIKSWA KRKFGFEENK IDRTFGIPED FDYIDLEHHH HHH
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 24.80 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 29 kDa band.
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Purity
>85%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Validations
Recombinant MND1 protein (His tag) SDS-PAGE
M: Marker; Lane 1: MND1; Lane 2: BSA
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"