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Product Name
Recombinant MMRN1 protein (His tag)
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Description
Recombinant Human Multimerin-1 (MMRN1) Fragment (aa 1045-1228) - A specialized research tool containing the complete C1q functional domain, ideal for investigating platelet factor V/Va carrier functions and integrin binding mechanisms in coagulation biology.
Multimerin-1 (EMILIN-4) is a crucial carrier protein specifically for platelet factor V/Va, playing a vital role in the storage and stabilization of factor V within platelets. Following platelet activation and release, it functions to limit platelet and plasma factor Va-dependent thrombin generation. The protein serves as a ligand for integrin alpha-IIb/beta-3 and integrin alpha-V/beta-3 on activated platelets, potentially acting as an extracellular matrix or adhesive protein. As a secreted protein, Multimerin-1 requires proper O-fucosylation at specific threonine residues (Thr-216 and Thr-1055) for efficient secretion, highlighting the importance of post-translational modifications for its biological function and localization.
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Protein name
Multimerin-1
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Uniprot ID
Q13201
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Gene Name
MMRN1; ECM; EMILIN4; GPIA*; MMRN
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 1045-1228 aa (Q13201) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 22.10 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 22 kDa band.
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Purity
>87%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"