mineralization nucleation (HAP) peptide

mineralization nucleation (HAP) peptide

• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

H-DDDEEKFLRRIGFG-OH

H-Asp-Asp-Asp-Glu-Glu-Lys-Phe-Leu-Arg-Arg-Ile-Gly-Phe-Gly-OH

14

95.51%

C₇₄H₁₁₃N₂₁O₂₅

1696.8

Synthetic

Powder

DDDEEKFLRRIGFG polypeptide is known for its role in nucleation of mineralization, which is crucial for processes like bone regeneration. It can be incorporated into elastin-like recombinamer (ELR) molecules, enhancing their bioactivity. The resulting ELR membranes with DDDEEKFLRRIGFG have shown promising in vitro properties, such as the ability to promote osteogenic differentiation of cells. They also exhibit good mechanical properties and biocompatibility due to the characteristics of the ELR structure. Overall, DDDEEKFLRRIGFG polypeptide offers a valuable option for creating bioactive materials that could have significant implications in the field of tissue engineering and regenerative medicine.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• Tejeda-Montes E, Klymov A, Nejadnik MR, Alonso M, Rodriguez-Cabello JC, Walboomers XF, Mata A. Mineralization and bone regeneration using a bioactive elastin-like recombinamer membrane. Biomaterials. 2014 Sep;35(29):8339-47. doi: 10.1016/j.biomaterials.2014.05.095. Epub 2014 Jul 2. PMID: 24996755.

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.