-
Product Name
Recombinant MFS2B protein (His tag)
- Documents
-
Description
Recombinant Human MFSD2B Protein Fragment (aa 37-112) - A highly stable and soluble fragment of the sphingosine-1-phosphate transporter MFSD2B, specifically engineered for structural and biochemical studies of lipid transport mechanisms in red blood cells and platelets.
MFSD2B is a crucial lipid transporter that specifically mediates the export of sphingosine-1-phosphate (S1P) in red blood cells and platelets. This signaling sphingolipid export is essential for maintaining proper red blood cell morphology and is required for platelet aggregation and thrombus formation. The transporter facilitates S1P export through a proton gradient mechanism and can handle various S1P species including sphinganine 1-phosphate, sphing-4-enine 1-phosphate, and sphinga-4E,14Z-dienine-1-phosphate. MFSD2B localizes to the cell membrane as a multi-pass membrane protein and does not transport lysophosphatidylcholine, demonstrating high specificity for sphingosine-1-phosphate transport. This makes it a critical component in understanding hematological function and thrombosis mechanisms.
-
Protein name
Sphingosine-1-phosphate transporter MFSD2B
-
Uniprot ID
A6NFX1
-
Gene Name
MFSD2B
-
Source/Expression Host
E. coli
-
Expression Plasmid/cDNA
DNA encoding 37-112 aa (A6NFX1) were fused with 6His tag.
-
Sequence
37-112
-
Protein Species
Human
-
Molecular weight
Predictes a molecular mass of 9.50 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 10 kDa band.
-
Purity
>90%, by SDS-PAGE with Coomassie Brilliant Blue staining.
-
Activity
Not tested.
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"