(Met186)-Melanocyte Protein PMEL 17, G209-2M; gp100 (209-217) peptide

(Met186)-Melanocyte Protein PMEL 17, G209-2M; gp100 (209-217) peptide

• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

IMDQVPFSV

H-Ile-Met-Asp-Gln-Val-Pro-Phe-Ser-Val-OH

9

95.3%

C₄₇H₇₄N₁₀O₁₄S

1035.23

181477-43-0

Synthetic

Powder

This modified sequence of the gp100 epitope gp(209-217) (H-4106), in which a methionine replaced the natural threonine at position 2, bound to the HLA-A2 molecule with greater affinity than the unmodified peptide and was shown to have an increased ability to generate melanoma-reactive cytotoxic T lymphocytes (CTLs) in vitro when used for sensitization of peripheral blood mononuclear cells. This synthetic peptide hold promise for the development of novel cancer immunotherapies.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• K.-H.Lee et al., J. Immunol., 161, 4183 (1998)
• S.A.Rosenberg et al., Nat. Med., 4, 321 (1998)
• S.A.Rosenberg et al., J. Immunol., 163, 1690 (1999)
• M.Fritsch et al., J. Immunother., 23, 557 (2000)
• M.E.Dudley et al., Cancer J., 6, 69 (2000)

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.