Melectin peptide

Melectin peptide

• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

GFLSILKKVLPKVMAHMK

Gly-Phe-Leu-Ser-Ile-Leu-Lys-Lys-Val-Leu-Pro-Lys-Val-Met-Ala-His-Met-Lys

18

96.3%

Synthetic

Powder

Using synthetic peptides, Pro11 was found to be important for peptide selectivity. Changes of Pro11 to Ala, Lys, and Gly or delection of Pro11 had little effect on antibacterial activities but increased the hemolytic activities. The antibacterial region is located at the N-terminus of the peptide (a peptide containing residues 1-10 is active). The peptide also exhibits mast cell degranulating activity. Also,the peptide was recently found to be HIV inhibitory (EC50=4.3 uM) (Wang G et al. 2010 Antimicrob. Agents Chemother. 54: 1343-1346). Melectin has Antibacterial activity. The source of Melectin is the Cleptoparasitic bee Melecta albifrons.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• Cerovský V, Hovorka O, Cvacka J, et al. Melectin: a novel antimicrobial peptide from the venom of the cleptoparasitic bee Melecta albifrons. Chembiochem. 2008;9(17):2815-21.

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.