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Product Name
Recombinant MCFD2 protein (His tag)
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Description
Recombinant Human MCFD2 Protein Fragment (42-146) offers a specialized research tool for investigating the EF-hand domains of Multiple coagulation factor deficiency protein 2. This high-purity fragment, derived from the human MCFD2 gene, enables focused studies on calcium-binding motifs critical for protein transport and coagulation factor secretion.
The full-length MCFD2 protein forms a complex with LMAN1 to create a specific cargo receptor that mediates endoplasmic reticulum-to-Golgi transport of selected proteins, particularly playing an essential role in the secretion of coagulation factors. This protein localizes to multiple compartments within the secretory pathway, including the endoplasmic reticulum, Golgi apparatus, and endoplasmic reticulum-Golgi intermediate compartment, highlighting its central function in intracellular protein trafficking and coagulation biology.
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Protein name
Multiple coagulation factor deficiency protein 2
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Uniprot ID
Q8NI22
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Gene Name
MCFD2; SDNSF
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 42-146 aa (Q8NI22) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 13.69 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 17 kDa band.
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Purity
>85%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"