Recombinant MBNL1 protein (His tag)

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Recombinant Human Muscleblind-like protein 1 (MBNL1) fragment (amino acids 1-102) is a high-purity, stable protein designed for structural and biochemical studies. This fragment represents a soluble unit of the full-length protein, which plays a critical role in regulating alternative splicing of pre-mRNA targets, making it ideal for investigating RNA-binding mechanisms and splicing regulation in research applications.

Muscleblind-like protein 1 (MBNL1) is a key regulator of pre-mRNA alternative splicing, functioning as both an activator and repressor for specific targets such as cardiac troponin-T (TNNT2) and insulin receptor (IR) pre-mRNAs. It binds to RNA consensus sequences like 5'-YGCU(U/G)Y-3' and competes with splicing factors such as U2AF2, inhibiting spliceosome complex formation on certain introns. MBNL1 localizes primarily to the nucleus but is also found in the cytoplasm and stress granules, and it is implicated in diseases like myotonic dystrophy due to its interaction with expanded CUG repeat RNAs. This protein fragment supports research into its functional domains and interactions without the complexities of the full-length protein.